To report a case of chryseobacterium indologenes ventilatorassociated pneumonia vap in a critically ill trauma patient. Incision and drainage was done and pus was sent for culture and sensitivity. Antimicrobial susceptibility and epidemiology of a. Chryseobacterium indologenes is a gramnegative, aerobic, nonfermenting, nonmotile, catalase, oxidase, and indole positive bacillus. We report for the first time a case of community acquired chryseobacterium indologenes soft tissue infection in an immunocompetent patient. Chryseobacteria can also colonize patients via contaminated medical devices such as respirators, intubation tubes, humidifiers. Chryseobacterium indologenes sepsis due to an infected centr. Limited data are available on chryseobacterium spp. Jul 26, 20 we report the seventh case of chryseobacterium indologenes occurring in the united states of america. Based on sequencing results of partial 16s rrna gene, isolates shared 99% identities e value 2e 50 with the 16s rrna sequence of c.
This report documents a rare case of chryseobacterium indologenes urinary tract infection in senegal. Typically thought of as an organism of low virulence, it may cause serious infections. Besides being rare, chryseobacterium indologenes, elizabethkingia meningoseptica and nonfermenting bacteria are considered opportunists. These 11 strains were found to cluster according to 16s rrna gene sequence similarity at a level of. Chryseobacterium indologenes, formerly known as flavobacterium indologenes or flavobacterium aureum belongs to cdc group iib. Chryseobacterium indologenes is a gramnegative and nonmotile bacteria from the genus of chryseobacterium which has been isolated from a human. Chryseobacterium indologenes is an uncommon human pathogen reported in hospital outbreaks in taiwan and there have been some sporadic cases reported in europe and in the usa mainly from immunesuppressed patients. Chryseobacterium indologenes is a pathogen of american bullfrogs lithobates catesbeianus and humans further reading. Herein, we report the first case in europe and the second case in an immunocompetent patient of peritoneal dialysisassociated c. Chryseobacterium respiratory tract infections in patients with cystic fibrosis. First isolation and characterization of chryseobacterium. Chryseobacterium indologenes was isolated from the blood cultures of an oncological patient with a totally implantable device. The genus flavobacterium was created in 1923 for a group of nonspore forming, aerobic gram negative rods, with the ability to produce yellow pigmented colonies 8. The lowest frequency has been reported in children under 5 year.
Pdf a case of noncatheterrelated bacteremia caused by. A threemonthold female infant born at term by caesarean section with meningomyelocele and congenital diaphragmatic hernia had two surgeries for the repair of meningomyelocele and diaphragmatic hernia on her. Some species cause opportunistic infections in severely immunosuppressed people. We present a case of ventilatorassociated pneumonia caused by c. In hospital environments, they have been recovered from water systems and humid surfaces. It can colonize hospital environment due to ability to survive in chlorinetreated water supplies. Unforeseeable presentation of chryseobacterium indologenes. It also exhibit nitrogen fixation ability around 19. Chryseobacterium indologenes bacteraemia in a diabetic child. A cluster of chryseobacterium indologenes cases related to drainage water in intensive care units volume 39 issue 8 mireia cantero, lina m. Pdf chryseobacterium indologenes is an uncommon human pathogen. Chryseobacterium indologenes bacteraemia in a diabetic.
Identification and virulence of chryseobacterium indologenes. There is a current unmet need to develop novel control measures including the identification and. Role of chryseobacterium indologenes infection in a female. Fifty isolates 24 chryseobacterium meningosepticum, 20 chryseobacterium indologenes, two chryseobacterium gleum, and 4 chryseobacterium spp. Chryseobacterium and elizabethkingia species may be long, thin, slightly curved, and occasionally filamentous on gram stain. Pdf chryseobacterium indologenes infection in a newborn. Antimicrobial susceptibility and epidemiology of a worldwide. Some species of chryseobacterium have been involved in human infections, acting as sporadic but severe. Chryseobacterium infections are uncommon, and previous studies have revealed that chryseobacterium. With 215 c indologenes isolates between january 1, 2004 and september 30, 2011, at a medical center, we analyzed the relationship between the prevalence of c indologenes infections and total prescription of colistin and tigecycline, clinical manifestation, antibiotic susceptibility, and outcomes. It is possible that physicians may encounter this pathogenic microorganism in hospital environment such as mechanical ventilator circuits.
Chryseobacterium indologenes although uncommon, is an important pathogen causing infection in hospitalized patients. Chryseobacterium indologenes and chryseobacterium gleum are human pathogens and are former members of the genus flavobacterium vandamme et al. Reported infections include bacteremia, pneumonia, meningitis, myositis, keratitis, and indwelling devices. A collection of eight clinical strains from belgian hospitals and three clinical strains of the ccug collection were characterized biochemically as being similar to cdc groups iih and iic. Clinical and epidemiological features of chryseobacterium. The management of this infection needs better identification, drug susceptibility testing and monitoring of immunosuppressed patients with long hospitalizations. Chryseobacterium species is gramnegative bacillus widely distributed in soil and water. Furthermore, strain gse06t exhibited the highest sequence similarities with type strains of chryseobacterium indologenes atcc 29897t 98. A 2yearold boy with type i diabetes mellitus was admitted due to. Chryseobacterium and acinetobacter flashcards quizlet. Pdf chryseobacterium respiratory tract infections in.
Recurrent bacteremia by chryseobacterium indologenes in an. Chryseobacterium indologenes is a widespread bacteria in the environment, especially hospitals, and a rarely reported human pathogen. Flavobacterium meningosepticum, cdc group iia bacteriology a bacterium of soil, water, plants, foods, hospital waterincubators, tap water, hemodialysis systems, pharmaceuticals mode of transmission uncertain, but probably linked to contaminated medical devices and fluids. Chryseobacterium indologenes a novel root nodule endophyte in vigna radiata archana dhole, harsha shelat and deepak panpatte anand agricultural university, anand, gujarat, india388110, india corresponding author a b s t r a c t bp. Dec 14, 2018 recently, chryseobacterium indologenes has become a notorious multidrug resistant nosocomial pathogen. A 11 year female child, from southasia of indian origin presented with fever, pain and swelling in right leg for 3 days with no significant past history. Chryseobacterium indologenes are aerobic, gram negative, nonfermentative rods that are intrinsically multidrug resistant. Chryseobacterium spp gramnegative, long thin bacilli with occasional swollen ends acinetobacter spp plump coccobacilli, tend to resist alcohol decolourisation may be mistaken for neisseria spp when found intracellularly archaic name mima to mimic. Some unofficial data says 150 to 170 miles ev with 35. It is ubiquitous and intrinsically resistant to several antibiotics. Formerly flavobacterium indologenes, chryserobacterium indologenes is a yellow pigmented, gramnegative filamentous, nonmotile rod and can be found in soil, plants, foodstuffs and water sources including those found in hospitals 1234. However, in rare cases it can cause serious infections, particularly among the immunocompromised. In 1994, vandamme and colleagues described a nonmotile, gramnegative, rodshaped, aerobic, nonlactosefermenting, catalase and oxidasepositive bacillus, which was classified in the genus chryseobacterium 2.
Chryseobacteria can also colonize patients via contaminated medical devices such as respirators, intubation tubes. Chryseobacterium definition of chryseobacterium by medical. Introduction we report the seventh case of chryseobacterium indologenes occurring in the united states of america. Chryseobacterium definition of chryseobacterium by. Chryseobacterium gleum, chryseobacterium odoratum, chryseobacterium multivorum, and chryseobacterium breve have more recently been reclassified into the genera myroides, sphingobacterium, and empedobacter. A cluster of chryseobacterium indologenes cases related to. Pdf chryseobacterium indologenes noncatheterrelated. Chryseobacterium indologenes, a nonmotile gramnegative rod, though widely distributed in nature, is an uncommon human pathogen. May 30, 2015 chryseobacterium indologenes pneumonia case presentation 1. The genus chryseobacterium, defined in 1994 by vandamme et al. Hendaus, khalid zahraldin department of pediatrics, hamad medical corporation, doha, qatar 3050. The highest chryseobacterium prevalence was detected among the elderly. After short stay in er she had being unstable and transferred to the icu. Oct 10, 2016 chryseobacterium indologenes is a widespread bacteria in the environment, especially hospitals, and a rarely reported human pathogen.
We present the clinical course of a 52yearold african male with a medical history of end stage renal disease esrd in hemodialysis with multiple episodes of. A case of healthcare associated pneumonia caused by. Chryseobacterium indologenes meningitis in a healthy. Chryseobacterium gleum and chryseobacterium indologenes, previously known as flavobacterium cdc group iib, have been clearly differentiated by dnadna homology and eight phenotypic characteristics. This report describes a 66yearold critically ill trauma patient who developed vap, which was caused by c indologenes. We report a second case in the united states in a patient with metastatic breast cancer who, while on chemotherapy. Incision and drainage was done and pus was sent for culture and. The first case was a known case of diabetes mellitus with. Chryseobacterium indologenes previously classified as flavobacterium indologenes is a gram. Chryseobacterium indologenes is an uncommon human pathogen, but the incidence of bacteremia has been increasing with use of broadspectrum antimicrobial agents. Emerging chryseobacterium indologenes infection in. The lowest frequency has been reported in children under 5 years of age. Chryseobacterium indologenes, an emerging bacteria. Ventilatorassociated pneumonia caused by chryseobacterium.
Chryseobacterium indologenes in a woman with metastatic. Elizabethkingia, chryseobacterium and myroides species. Because of the lack of knowledge of their existence, as well as difficulty characterizing them and their restricted options for. Apr 06, 2016 chryseobacterium indologenes, a nonmotile gramnegative rod, though widely distributed in nature, is an uncommon human pathogen. The genus is composed of six species where chryseobacterium meningosepticum,incurrent taxonomy named elizabethkingia meningosepticum,is reported as the most pathogenic, while c. Cureus chryseobacterium indologenes, an emerging bacteria. We present the clinical course of a 52yearold african male with a medical history of end stage renal disease esrd in hemodialysis with multiple. Peritonitis remains an important complication of peritoneal dialysis. A case of noncatheterrelated bacteremia caused by chryseobacterium indologenes in a nonneutropenic man with a solid tumor is described. We investigated clinical characteristics and treatment outcomes for c.
Six cases have been recorded in europe, 2 in australia, and a single case in the united states. Chryseobacterium indologenes meningitis in a healthy newborn. The golden death bacillus chryseobacterium nematophagum is. Emerging chryseobacterium indologenes infection in indian. Infection by multidrugresistant chryseobacterium indologenes. Fifty isolates 24 chryseobacterium meningosepticum, 20 chryseobacterium indologenes, two chryseobacterium gleum, and 4 chryseobacterium. Fifty isolates 24 chryseobacterium meningosepticum, 20 chryseobacterium indologenes, two. Case presentation a 32yearold caucasian woman with metastatic breast cancer presented to a hospital emergency department with bilateral radiationinduced pleural effusions and respiratory failure. Chryseobacterium indologenes is a nonlactosefermenting, gramnegative, health careassociated pathogen hcap.
Chryseobacterium indologenes pneumonia case presentation 1. The golden death bacillus chryseobacterium nematophagum is a. Differences in clinical manifestations, antimicrobial susceptibility. Members the genus chryseobacterium are widely distributed microorganisms that can be recovered from a wide variety of environments, such as fresh water, sewage and wastewater, soil or food sources, such as milk, poultry and meat and dairy products. In 1994, vandamme and colleagues described a nonmotile, gramnegative, rodshaped, aerobic, nonlactosefermenting, catalase and oxidasepositive bacillus, which was classified in the genus chryseobacterium. The newly classified and renamed elizabethkingia, chryseobacterium and myroides genera were originally included among the different species that belong to the genus flavobacterium. Chryseobacterium indologenes is an uncommon human pathogen that has been rarely reported in the literature as a cause of infection, but despite low virulence, this opportunistic bacteria is resistant to many antimicrobial agents. We report three cases of complicated urinary tract infections utis caused by chryseobacterium indologenes in patients with obstructive uropathy.
Chryseobacterium indologenes, a possible emergent organism resistant to carbapenem antimicrobials after stem cell transplantation article pdf available december 2016 with 64 reads how we. Chryseobacterium indologenes pneumonia case presentation. Evaluation of treatment outcomes for chryseobacterium. Chryseobacterium gleum holmes, owen, steigerwalt and brenner 1984b vandamme, bernardet, segers, kersters and holmes 1994a, 830 vp flavobacterium gleum holmes, owen, steigerwalt and brenner 1984b, 23. Chryseobacterium indologenes is an emerging nosocomial pathogen that produces indtype chromosomal metallobetalactamase. Apr 12, 2016 we report for the first time a case of community acquired chryseobacterium indologenes soft tissue infection in an immunocompetent patient. Chryseobacterium indologenes although ubiquitous in nature, mainly found in soil and water, is an uncommon human pathogen. Chryseobacterium indologenes is an uncommon organism that has been documented to cause a variety of invasive infections mostly in hospitalized patients with severe underlying diseases. Chryseobacterium indologenes infection in a newborn.
Chryseobacterium indologenes, previously called flavobacterium, has been reported to cause hospitalacquired infections mostly in taiwan but rarely elsewhere. Although this bacterium only rarely causes human disease, it is sometimes found in food and water sources, usually in hospitals as a nosocomial transinfection. There is a current unmet need to develop novel control measures including the. Jan 14, 2011 chryseobacterium indologenes is an uncommon human pathogen. The patient was injured in a riding lawn mower accident that trapped him underwater in a pond. Chryseobacterium indologenes is nonmotile, oxidase, and indole positive gramnegative aerobic bacilli which is widely found in plants, soil, foodstuffs, and water.
Chryseobacterium indologenes in a woman with acute. A 32yearold caucasian woman with metastatic breast cancer presented to a hospital emergency department with bilateral radiationinduced pleural effusions and. The genus chryseobacterium includes six species that were previously designated members of the genus flavobacterium. Based on fatty acid methyl ester analysis, isolates were found to share similarities with c.
The gramnegative bacillus chryseobacterium indologenes causes infection mostly in immunocompromised patients with severe underlying disease, mainly in asia. Most infections have been detected in hospitalized patients with severe underlying diseases who had indwelling devices implanted. Chryseobacterium indologenes, a possible emergent organism. Most infections have been detected in hospitalized patients with severe underlying diseases who had indwelling devices. Typically thought of as an organism of low virulence, it may cause serious infections, particularly among the immunocompromised. Antibioticresistant pathogens and nosocomial infections constitute common and serious problems for neonates admitted to neonatal intensive care units worldwide. Chryseobacterium indologenes a novel root nodule endophyte in. Treatment of chryseobacterium indologenes ventilator. Pdf chryseobacterium indologenes, a possible emergent. It is widely distributed in environmental sources including water, soil and plants omar et al. We report a rare case of urinary tract infection by chryseobacterium indologenes in a young girl, operated for renal calculus and successfully treated with piperacillintazobactam combination. Its occurrence in diabetic children has not been previously reported.
Chryseobacterium indologenes is a nonfermentative gramnegative bacillus that is a rare pathogen in humans. Chryseobacterium indologenes an overview sciencedirect. The phenotype and molecular aspects of two multidrug resistant c. The patient was injured in a riding lawn mower accident that trapped him. Urinary tract infection by chryseobacterium indologenes. The patient was successfully treated with piperacillintazobactam. Challenges in the identification of chryseobacterium. Molecular characterization of chryseobacterium indologenes. Identification of species and susceptibility tests were performed using the vitek2. Chryseobacterium indologenes is an uncommon human pathogen.
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